CLRA Resiman blog post

July 18, 2023

Long-Coding RNAs in Blood Cancer, Leukemia, and Myeloma Research

Leukemia research stands at the forefront of the battle against cancer, holding immense potential to transform lives and shape the future of medical science. Dr. David Riesman, a renowned virologist and biology expert, has dedicated his career to unraveling the intricate connection between viruses and cancer. His groundbreaking blood cancer research, focused on the Epstein Barr virus and its role in leukemia, has gained recognition and received vital support from the Children’s Leukemia Research Association. Children’s Leukemia Research Association’s own Angela Russo sat down with Dr. Reisman to discuss ongoing research advancements, including the critical role of long coding RNAs in gene regulation.

Gene regulation is a complex process through which cells control their gene expression, crucial for maintaining normal cellular functions. In recent years, long coding RNAs, once dismissed as “junk DNA,” have emerged as essential players in orchestrating gene expression. These noncoding RNA molecules regulate various cellular processes, including differentiation, development, and disease progression.

Thanks to the invaluable support of the Children’s Leukemia Research Association, Dr. Riesman is at the forefront of a groundbreaking research project focusing on a specific long noncoding RNA found in myeloid leukemias. This RNA is overexpressed in leukemia cells and contributes to the blockage of differentiation, a defining characteristic of these malignant cells. Dr. Riesman’s comprehensive research plan aims to unravel the intricate signaling pathways and genes regulated by this long noncoding RNA, as well as identify the cellular factors it interacts with. Ultimately, this understanding can pave the way for targeted therapies that induce differentiation in leukemia cells, offering improved treatment outcomes.

Dr. Riesman’s interview with CLRA highlights his optimism and enthusiasm for the progress made thus far in his research. With the unwavering support of the Children’s Leukemia Research Association, significant advancements have been made in comprehending the underlying mechanisms of leukemia and the potential for innovative therapeutic interventions. Dr. Riesman’s investigation into the role of long coding RNAs not only contributes to our understanding of cancer but also brings hope to individuals and families affected by this devastating disease.

Dr. David Riesman’s research plan embodies the power of scientific exploration and collaborative efforts. By delving into the intricate world of long coding RNAs, Dr. Riesman’s groundbreaking research sheds light on the underlying mechanisms of leukemia and holds the potential to revolutionize treatment outcomes. Through the invaluable support of the Children’s Leukemia Research Association and generous donations, we can continue fueling this life-saving research and moving closer to a future where leukemia is defeated. Together, let us unveil the secrets of leukemia and offer hope to those in need.

Conducting research of this magnitude requires substantial resources, and this is where the Children’s Leukemia Research Association plays a pivotal role. Generous donations from individuals and organizations empower researchers like Dr. Riesman to pursue groundbreaking studies, conduct essential experiments, and explore novel treatment strategies. Each dollar contributed brings us closer to a world where leukemia is no longer a life-threatening diagnosis.

ABOUT DR. RESIMAN: David Riesman is a distinguished professor, Michael J Mungo Distinguished Professor Award recipient, and esteemed department chair at the University of South Carolina where he spearheads cutting-edge research in virology. With his profound knowledge of biology and expertise in viruses, Dr. Riesman plays a pivotal role in unraveling the intricate mechanisms underlying cancer development.